condition Bleeding Disorders

Overview

A bleeding disorder is any problem with how the body makes a blood clot. Different bleeding disorders are missing different clotting factors or have a problem with a part of the blood, like platelets. Some bleeding disorders, like hemophilia A or B and von Willebrand’s Disease, are passed down in families. These are rare and affect < 1% of people. Other bleeding disorders like anemia and low platelet counts can develop over time due to other health problems and are more common. Symptoms can include bruising easily, frequent nosebleeds, and bleeding more or for longer than usual. Women may have heavy periods. Treatment for the inherited bleeding disorders replaces the missing or defective clotting factor. Gene therapies are also available for the hemophilias. For other bleeding disorders, medications increase production of blood components.

Drug Therapies

  • Aranesp

    Aranesp (darbepoetin alfa)

    Aranesp (darbepoetin alfa) mimics endogenous erythropoietin to increase the production of red blood cells in patients with anemia due to chronic kidney disease or certain chemotherapy treatments.
    Manufacturer:
    Amgen
    Route of Administration: 
    Subcutaneous, Intravenous
    Site of Care:
    Outpatient
    Website: 
    • https://www.aranesp.com
    Enrollment Forms:
    Synergen Prescription Form

    Approved Indication:

    • treatment of anemia due to chronic kidney disease in patients on dialysis and patients not on dialysis
    • treatment of anemia due to the effects of concomitant myelosuppressive chemotherapy in patients who cannot be managed by transfusion, who do not require immediate correction of anemia, and who are NOT receiving biologic products, hormonal agents, or radiotherapy without concomitant myelosuppressive chemotherapy

    Conditions:

    • Chronic Kidney Disease
    • Anemia of Chronic Kidney Disease
    • Chemotherapy-Induced Anemia

      Therapeutic Area:

      • Oncology
      less details
    • Epogen

      Epogen (epoetin alfa)

      Epogen (epoetin alfa) is a synthetic protein that promotes the production of new red blood cells in patients with certain types of anemia.
      Manufacturer:
      Amgen
      Route of Administration: 
      Subcutaneous, Intravenous
      Site of Care:
      Outpatient
      Website: 
      • https://www.epogen.com
      phone: 
      866-264-2778
      Enrollment Forms:
      Synergen Prescription Form

      Approved Indication:

      • treatment of anemia due to chronci kidney disease in patients on dialysis and not on dialysis
      • treatment of anemia due to zidovudine in patients with HIV infection
      • treatment of anemia due to the effects of concomitant myelosuppressive chemotherapy (upon initiation, a minimum of two additional months of planned chemotherapy required)
      • reducing allogenic red blood cell transfusions in patients undergoing elective, noncardiac, nonvascular surgery

      Conditions:

      • Anemia

        Therapeutic Area:

        • Nephrology
        • Oncology
        less details
      • Feraheme

        Feraheme (ferumoxytol)

        Feraheme (ferumoxytol) is an iron oxide infusion used to treat anemia by supporting the formation of hemoglobin.
        Manufacturer:
        Amag Pharmaceuticals
        Route of Administration: 
        Intravenous
        Site of Care:
        Outpatient
        Website: 
        • https://feraheme.com
        phone: 
        1-844-635-2624
        Enrollment Forms:
        Synergen Prescription Form
        Patient Support Form

        Approved Indication:

        treatment of iron deficiency anemia in adult patients with chronic kidney disease

        Conditions:

        • Anemia

          Therapeutic Area:

          • Nephrology
          less details
        • Injectafer

          Injectafer (ferric carboxymaltose)

          Injectafer (ferric carboxymaltose) is an iron infusion used to treat anemia by supporting the formation of hemoglobin.
          Manufacturer:
          Daiichi-Sankyo
          Route of Administration: 
          Intravenous
          Site of Care:
          Outpatient
          Website: 
          • https://injectafer.com
          phone: 
          866-4-DSI-NOW (1-866-437-4669)
          Enrollment Forms:
          Synergen Prescription Form
          Patient Support Form

          Approved Indication:

          • treatment of iron deficiency anemia in adult and pediatric patients 1 year of age and older who have either intolerance or an unsatisfactory response to oral iron
          • treatment of iron deficiency anemia in adult patients with non-dialysis dependent chronic kidney disease
          • treatment of iron deficiency in adult patients with heart failure and New York Heart Association class II/III to improve exercise capacity

          Conditions:

          • Iron Deficiency Anemia

            Therapeutic Area:

            • Nephrology
            less details
          • Procrit

            Procrit (epoetin alfa)

            Procrit (epoetin alfa) is a synthetic protein that promotes the production of new red blood cells in patients with certain types of anemia.
            Manufacturer:
            Johnson & Johnson
            Route of Administration: 
            Subcutaneous, Intravenous
            Site of Care:
            Outpatient
            Website: 
            • https://www.procrit.com
            Enrollment Forms:
            Synergen Prescription Form

            Approved Indication:

            • treatment of anemia due to chronci kidney disease in patients on dialysis and not on dialysis
            • treatment of anemia due to zidovudine in patients with HIV infection
            • treatment of anemia due to the effects of concomitant myelosuppressive chemotherapy (upon initiation, a minimum of two additional months of planned chemotherapy required)
            • reducing allogenic red blood cell transfusions in patients undergoing elective, noncardiac, nonvascular surgery

            Conditions:

            • Anemia

              Therapeutic Area:

              • Nephrology
              • Oncology
              less details
            • Retacrit

              Retacrit (epoetin alfa-epbx)

              Retacrit (epoetin alfa-epbx) is a biosimilar to Epogen. Like Epogen, Retacrit is a synthetic protein that promotes the production of new red blood cells in patients with certain types of anemia.
              Manufacturer:
              Pfizer
              Route of Administration: 
              Subcutaneous, Intravenous
              Site of Care:
              Outpatient
              Website: 
              • https://retacrit.pfizerpro.com
              phone: 
              1-877-744-5675
              Enrollment Forms:
              Synergen Prescription Form
              Patient Support Form

              Approved Indication:

              • treatment of anemia due to chronci kidney disease in patients on dialysis and not on dialysis
              • treatment of anemia due to zidovudine in patients with HIV infection
              • treatment of anemia due to the effects of concomitant myelosuppressive chemotherapy (upon initiation, a minimum of two additional months of planned chemotherapy required)
              • reducing allogenic red blood cell transfusions in patients undergoing elective, noncardiac, nonvascular surgery

              Conditions:

              • Anemia

                Therapeutic Area:

                • Nephrology
                • Oncology
                less details
              • Vafseo

                Vafseo (vadadustat)

                Vafseo (vadadustat) inhibits the enzyme hypoxia-inducible factor prolyl hydroxylase to increase levels of erythropoietin and promote the production of red blood cells in patients with anemia due to kidney failure.
                Manufacturer:
                Akebia Therapeutics
                Route of Administration: 
                Oral
                Site of Care:
                Outpatient
                Website: 
                • https://www.vafseo.com
                phone: 
                1-855-686-8601
                Enrollment Forms:
                Synergen Prescription Form
                Patient Support Form

                Approved Indication:

                treatment of anemia due to chronic kidney disease in adults who have been receiving dialysis for at least three months

                Conditions:

                • Anemia
                • Chronic Kidney Disease

                  Therapeutic Area:

                  • Nephrology
                  less details
                • Venofer

                  Venofer (iron sucrose)

                  Venofer (iron sucrose) is an iron infusion used to treat anemia by supporting the formation of hemoglobin.
                  Manufacturer:
                  American Regent
                  Route of Administration: 
                  Intravenous
                  Site of Care:
                  Outpatient
                  Website: 
                  • https://www.venofer.com
                  phone: 
                  877-448-4766
                  Enrollment Forms:
                  Synergen Prescription Form
                  Patient Support Form

                  Approved Indication:

                  treatment of iron deficiency anemia in adult patients with chronic kidney disease

                  Conditions:

                  • Iron Deficiency Anemia

                    Therapeutic Area:

                    • Nephrology
                    less details

                  Resources

                  Understanding a diagnosis can feel overwhelming. These resources link to well-established organizations, for in-depth education, research, and support.

                  American Society of Hematology
                  Hemophilia Federation of America
                  National Bleeding Disorders Foundation

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